Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC063
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-10-18 10:37
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment OLD PATIENT MADOPAR 250MG 3X1\2

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 2 individuals with a value less than 0.51 were subsequently diagnosed with PD. That is, 4.76% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.51 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 26, 'TN': 22, 'TP': 16, 'FP': 8}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 20, 'TN': 14, 'TP': 22, 'FP': 16}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 6, 'TN': 6, 'TP': 36, 'FP': 24}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 5, 'TN': 3, 'TP': 37, 'FP': 27}

Test Battery Details

Circle

numCircles 6
timePerCircleMean 10.2933
timePerCircleCoV 0.0778626
timePerCircleSlope -0.0368616
meanError 1.80982
tremorFreq 5.95703
tremorRelPower 70.5594
tremorGyroAmpMean 0.331355
tremorGyroAmpSlope -0.00512256
tremorGyroAmpCoV 0.526474
tremorCoordAmpMean 0.419337
tremorCoordAmpSlope -0.000990791
tremorCoordAmpCoV 0.428671
tremorAccAmpMean 0.364513
tremorAccAmpSlope -0.000598165
tremorAccAmpCoV 0.434222
tremorPcRelVar 0.884577
tremorPcX -0.833808
tremorPcY 0.552055

Circle Segment 1

Duration 10.88 s, Accuracy Estimate 1.52 (lower is better)

Circle Segment 2

Duration 11.44 s, Accuracy Estimate 1.596 (lower is better)

Circle Segment 3

Duration 10.36 s, Accuracy Estimate 1.789 (lower is better)

Circle Segment 4

Duration 10.24 s, Accuracy Estimate 1.886 (lower is better)

Circle Segment 5

Duration 9.32 s, Accuracy Estimate 2.037 (lower is better)

Circle Segment 6

Duration 9.52 s, Accuracy Estimate 2.031 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 21.56
timePerSpiralCoV 0.0808512
timePerSpiralSlope -0.0111992
meanError 2.58991
tremorFreq 5.56641
tremorRelPower 69.7256
tremorGyroAmpMean 0.259829
tremorGyroAmpSlope -0.00036834
tremorGyroAmpCoV 0.785914
tremorCoordAmpMean 0.414872
tremorCoordAmpSlope -0.000303806
tremorCoordAmpCoV 0.737188
tremorAccAmpMean 0.305042
tremorAccAmpSlope -0.0004522
tremorAccAmpCoV 0.577849
tremorPcRelVar 0.758724
tremorPcX 0.789498
tremorPcY -0.613753

Spiral Segment 1

Duration 24.36 s, Accuracy Estimate 2.324 (lower is better)

Spiral Segment 2

Duration 21.4 s, Accuracy Estimate 2.539 (lower is better)

Spiral Segment 3

Duration 20.64 s, Accuracy Estimate 3.503 (lower is better)

Spiral Segment 4

Duration 22.96 s, Accuracy Estimate 2.653 (lower is better)

Spiral Segment 5

Duration 21.4 s, Accuracy Estimate 2.158 (lower is better)

Spiral Segment 6

Duration 19.72 s, Accuracy Estimate 2.503 (lower is better)

Spiral Segment 7

Duration 20.72 s, Accuracy Estimate 2.33 (lower is better)

Spiral Segment 8

Duration 24.04 s, Accuracy Estimate 2.356 (lower is better)

Spiral Segment 9

Duration 21.32 s, Accuracy Estimate 2.667 (lower is better)

Spiral Segment 10

Duration 19.04 s, Accuracy Estimate 2.865 (lower is better)

Elel

eDurationMean 0.322424
eDurationStd 0.0786221
eDurationStdnorm 0.243847
eDurationMedian 0.305
eDurationQuartdelta 0.075
eDurationQuartdeltanorm 0.245902
eDurationKurt 8.05948
eDurationTrenddiff -0.04
eDurationTrendratio 0.878788
eWidthMean 4.68
eWidthStd 1.22187
eWidthStdnorm 0.261082
eWidthMedian 4.446
eWidthQuartdelta 1.72575
eWidthQuartdeltanorm 0.388158
eWidthKurt 2.7813
eWidthTrenddiff -0.4095
eWidthTrendratio 0.915663
eHeightMean 8.43109
eHeightStd 2.86604
eHeightStdnorm 0.339937
eHeightMedian 8.073
eHeightQuartdelta 2.691
eHeightQuartdeltanorm 0.333333
eHeightKurt 6.4303
eHeightTrenddiff -0.117
eHeightTrendratio 0.985612
eAspectMean 0.606962
eAspectStd 0.206235
eAspectStdnorm 0.339782
eAspectMedian 0.62069
eAspectQuartdelta 0.142881
eAspectQuartdeltanorm 0.230197
eAspectKurt 3.09806
eAspectTrenddiff 0.00644353
eAspectTrendratio 1.01046
eSlantMean 0.115926
eSlantStd 0.250227
eSlantStdnorm 2.1585
eSlantMedian 0.120879
eSlantQuartdelta 0.243299
eSlantQuartdeltanorm 2.01275
eSlantKurt 6.47508
eSlantTrenddiff -0.0582356
eRtopMean 0.809402
eRtopStd 0.183701
eRtopStdnorm 0.226959
eRtopMedian 0.833333
eRtopQuartdelta 0.227934
eRtopQuartdeltanorm 0.273521
eRtopKurt 3.12965
eRtopTrenddiff -0.0103769
eRbotMean 0.697815
eRbotStd 0.54172
eRbotStdnorm 0.776308
eRbotMedian 0.648649
eRbotQuartdelta 0.300438
eRbotQuartdeltanorm 0.463175
eRbotKurt 21.216
eRbotTrenddiff 0.043698
eRrightMean 0.796796
eRrightStd 0.412443
eRrightStdnorm 0.517628
eRrightMedian 0.8875
eRrightQuartdelta 0.122457
eRrightQuartdeltanorm 0.137979
eRrightKurt 25.4486
eRrightTrenddiff 0.0623105
eRleftMean 0.370875
eRleftStd 0.173897
eRleftStdnorm 0.468884
eRleftMedian 0.351351
eRleftQuartdelta 0.158978
eRleftQuartdeltanorm 0.452476
eRleftKurt 5.50411
eRleftTrenddiff -0.0939531
lDurationMean 0.348529
lDurationStd 0.0932456
lDurationStdnorm 0.26754
lDurationMedian 0.335
lDurationQuartdelta 0.06
lDurationQuartdeltanorm 0.179104
lDurationKurt 9.5251
lDurationTrenddiff -0.04
lDurationTrendratio 0.885714
lWidthMean 5.84312
lWidthStd 2.12871
lWidthStdnorm 0.364311
lWidthMedian 5.499
lWidthQuartdelta 2.106
lWidthQuartdeltanorm 0.382979
lWidthKurt 3.31675
lWidthTrenddiff 0.468
lWidthTrendratio 1.08889
lHeightMean 13.3793
lHeightStd 1.94479
lHeightStdnorm 0.145358
lHeightMedian 13.104
lHeightQuartdelta 1.521
lHeightQuartdeltanorm 0.116071
lHeightKurt 12.6368
lHeightTrenddiff -0.585
lHeightTrendratio 0.956522
lAspectMean 0.444105
lAspectStd 0.170522
lAspectStdnorm 0.383968
lAspectMedian 0.408194
lAspectQuartdelta 0.178537
lAspectQuartdeltanorm 0.437382
lAspectKurt 2.79325
lAspectTrenddiff 0.0589623
lAspectTrendratio 1.15723
lSlantMean 0.145051
lSlantStd 0.143962
lSlantStdnorm 0.992492
lSlantMedian 0.139766
lSlantQuartdelta 0.197115
lSlantQuartdeltanorm 1.41033
lSlantKurt 2.61835
lSlantTrenddiff 0.135859
lRtopMean 0.898628
lRtopStd 0.135983
lRtopStdnorm 0.151323
lRtopMedian 0.899189
lRtopQuartdelta 0.171429
lRtopQuartdeltanorm 0.190648
lRtopKurt 6.06186
lRtopTrenddiff 0.0867209
lRbotMean 0.609371
lRbotStd 0.262201
lRbotStdnorm 0.430281
lRbotMedian 0.629779
lRbotQuartdelta 0.319109
lRbotQuartdeltanorm 0.5067
lRbotKurt 3.06795
lRbotTrenddiff -0.220168
lRrightMean 0.915671
lRrightStd 0.0955863
lRrightStdnorm 0.104389
lRrightMedian 0.958247
lRrightQuartdelta 0.131379
lRrightQuartdeltanorm 0.137104
lRrightKurt 2.98837
lRrightTrenddiff 0.0719376
lRleftMean 0.330103
lRleftStd 0.166194
lRleftStdnorm 0.503463
lRleftMedian 0.35257
lRleftQuartdelta 0.201175
lRleftQuartdeltanorm 0.570596
lRleftKurt 2.90145
lRleftTrenddiff -0.104099

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

Elel Segment 13

FITTS Short Modified

meanTouchScore 0.809293
sumTouchScores 28.3252
meanMovementTime 0.547206
numTouches 35
undershootPercentage 0
overshootPercentage 25.7143

FITTS Long Modified

meanTouchScore 0.827804
sumTouchScores 10.7615
meanMovementTime 1.46875
numTouches 13
undershootPercentage 0
overshootPercentage 23.0769

ZigZag

numZigzags 6
timePerZigzagMean 17.2133
timePerZigzagCoV 0.0850093
timePerZigzagSlope 0.0260263
meanError 2.25847
tremorFreq 6.05469
tremorRelPower 53.6585
tremorGyroAmpMean 0.196918
tremorGyroAmpSlope 0.00097391
tremorGyroAmpCoV 0.315621
tremorCoordAmpMean 0.337986
tremorCoordAmpSlope 0.00127216
tremorCoordAmpCoV 0.430972
tremorAccAmpMean 0.254783
tremorAccAmpSlope 0.00236696
tremorAccAmpCoV 0.389329
tremorPcRelVar 0.734034
tremorPcX -0.549498
tremorPcY 0.835495

ZigZag Segment 1

Duration 14.92 s, Accuracy Estimate 2.562 (lower is better)

ZigZag Segment 2

Duration 16.76 s, Accuracy Estimate 1.978 (lower is better)

ZigZag Segment 3

Duration 17.36 s, Accuracy Estimate 1.983 (lower is better)

ZigZag Segment 4

Duration 19.4 s, Accuracy Estimate 2.233 (lower is better)

ZigZag Segment 5

Duration 17.84 s, Accuracy Estimate 2.385 (lower is better)

ZigZag Segment 6

Duration 17.0 s, Accuracy Estimate 2.41 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 13.104
timePerZigzagCoV 0.074446
timePerZigzagSlope 0.0369353
zigzagHeightMean 55.3585
zigzagHeightCoV 0.0880424
zigzagHeightSlope -0.0468852
meanError 0.0440433
tremorFreq 4.88281
tremorRelPower 68.3663
tremorGyroAmpMean 0.127013
tremorGyroAmpSlope 7.30318e-05
tremorGyroAmpCoV 0.331282
tremorCoordAmpMean 0.385161
tremorCoordAmpSlope -0.00212218
tremorCoordAmpCoV 0.862734
tremorAccAmpMean 0.191971
tremorAccAmpSlope -0.00366463
tremorAccAmpCoV 0.261009
tremorPcRelVar 0.828811
tremorPcX 0.185496
tremorPcY 0.982645

ZigZag Offset Segment 1

Duration 11.64 s, Accuracy Estimate 0.045 (lower is better)

ZigZag Offset Segment 2

Duration 12.76 s, Accuracy Estimate 0.061 (lower is better)

ZigZag Offset Segment 3

Duration 13.56 s, Accuracy Estimate 0.031 (lower is better)

ZigZag Offset Segment 4

Duration 14.24 s, Accuracy Estimate 0.038 (lower is better)

ZigZag Offset Segment 5

Duration 13.32 s, Accuracy Estimate 0.045 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.8}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.51}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.3194127452762716}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8967204944279656}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.4005964388142639}